PUBLICATIONS
2024
Selective utilization of glucose metabolism guides mammalian gastrulation. Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox AL, Greco V, Steventon B & Sozen B✉. Selective utilization of glucose metabolism guides mammalian gastrulation. Nature. 2024 Oct 16. doi: 10.1038/s41586-024-08044-1. Epub ahead of print. PMID: 39415005.
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Xin T✉, Gallini S, Wei H, Gonzalez DG, Matte-Martone C, Machida H, Fujiwara H, Pasolli HA, Suozzi KC, Gonzalez LE, Regot S✉ & Greco V✉. Nat Cell Biol. Jun 26, 2024. doi: 10.1038/s41556-024-01413-y. Epub Apr 30, 2024 [bioRxiv]
The art of observation: bridging science and art to see the unexpected. Gonzalez LE, Wei H, Greco V & Friedlaender LK. Development. Mar 1, 2024. doi.org/10.1242/dev.202786
NEWS
Leading Regulatory and Public Policy Actions to Advance the Field - ISSCR News (Message from the President). Nov 12, 2024
The Annual Meeting Program Highlights the Breadth of Global Talent - ISSCR News (Message from the President). Oct 8, 2024
Developmental and stem cell biologist Valentina Greco on building inclusivity by embracing difficult conversations and different perspectives - Cell Press. Sept 18, 2024
What Is Scientific Excellence and What Is the Role of Celebrating It? - ISSCR News (Message from the President). Sept 10, 2024
Expanding Internationality, Embracing Inclusivity, and Empowering Early Career Scientists - ISSCR News (Message from the President). Aug 13, 2024
Ep. 271: “Skin Regeneration” Featuring Dr. Valentina Greco - The Stem Cell Podcast. Jul 9, 2024
In the Early Steps of Cancer Formation, Timing Matters - Yale Medicine. Apr 30, 2024
2023
Organ function is preserved despite reorganization of niche architecture in the hair follicle. Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S, Gonzalez LE, Xin T✉ & Greco V✉. Cell Stem Cell. Jul 6, 2023. doi.org/10.1016/j.stem.2023.06.003 [bioRxiv]
Injury prevents Ras mutant cell expansion in mosaic skin. Gallini S, Annusver K, Rahman N, Gonzalez DG, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi KC, Kasper M✉ & Greco V✉. Nature. Jun 21, 2023. doi.org/10.1038/s41586-023-06198-y [bioRxiv]
A Spatiotemporal Compartmentalization of Glucose Metabolism Guides Mammalian Gastrulation Progression. Cao D, Zhong L, Hemalatha A, Bergmann J, Cox AL, Greco V & Sozen B✉. bioRxiv. Jun 8, 2023. doi.org/10.1101/2023.06.06.543780
Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Sola P, Solanas G, Bonjoch J, Marsh ED, Hirschi KK✉ & Greco V✉. Cell. May 25, 2023. doi.org/10.1016/j.cell.2023.04.017 [bioRxiv]
Cell cycle controls long-range calcium signaling in the regenerating epidermis. Moore J*, Bhaskar D*, Gao F*, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz NC, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswarmy S✉ & Greco V✉. Journal of Cell Biology. Apr 27, 2023. doi.org/10.1083/jcb.202302095 [bioRxiv]
Capturing Spatiotemporal Signaling Patterns in Cellular Data with Geometric Scattering Trajectory Homology. Bhaskar D, Moore JL, Gao F, Rieck B, Khasawneh F, Munch E, Greco V & Krishnaswamy S✉. bioRxiv. Mar 24, 2023. doi.org/10.1101/2023.03.22.533807
Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo. May D*, Yun S*, Gonzalez DG, Park S, Chen Y, Lathrop E, Cai B, Xin T, Zhao H, Wang S, Gonzalez LE✉, Cockburn K✉ & Greco V✉. eLife. Mar 20, 2023. doi.org/10.7554/eLife.83444 [bioRxiv]
NEWS
The Year in Cell Biology: 2023 - Rockefeller University Press. 2023
Making Science Stronger: Valentina Greco Talks Collaboration, Leadership, and Philanthropy - NYSCF. Aug 9, 2023
A Tale of Four Studies: Valentina Greco’s Lab Uncovers the Fascinating Dynamics of Skin Regeneration - NYSCF. Jul 17, 2023
The PHATE of basal epidermal cells: Calcium signaling during the cell cycle - Elsevier. Jun 14, 2023
Calling long distance: Cell cycle–dependent Ca2+ flows connect stem cells across regeneration tissues. Journal of Cell Biology. Jun 14, 2023
How stem cells organize cellular replacements - Yale News. Apr 28, 2023
2022
Susan L. Solomon (1951–2022): Advocate, Innovator, Catalyst. Fossati V, Greco V, Arlotta P & Aiyar RS✉. Stem Cell Reports. Dec 13, 2022. doi.org/10.1016/j.stemcr.2022.11.013
Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis in vivo. Hemalatha A, Li Z, Tai K, Gonzalez DG, Lathrop E, Gil D, Matte-Martone C, Ganesan S, Yun S, Gonzalez LE, Skala M, Perry RJ✉ & Greco V✉. bioRxiv. Nov 23, 2022. doi.org/10.1101/2022.11.21.517380
Double knockin mice show NF-kB trajectories in immune signaling and aging. Rahman S, Aqdas M, Martin EW, Ardori FT, Songkiatisak P, Oh K, Uderhardt S, Yun S, Claybourne QC, McDevitt RA, Greco V, Germain RN, Tessarollo L, & Sung M✉. Cell Reports. Nov 22, 2022. doi.org/10.1016/j.celrep.2022.111682
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer. Cockburn K, Annusver K, Gonzalez DG, Ganesan S, May DP, Mesa KR, Kawaguchi K, Kasper M✉ & Greco V✉. Nature Cell Biology. Nov 10, 2022. doi.org/10.1038/s41556-022-01021-8 [bioRxiv]
Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks. Yamamoto T✉, Katie Cockburn K, Greco V & Kawaguchi K✉. PLOS Computational Biology. Sept 6, 2022. doi.org/10.1371/journal.pcbi.1010477 [bioRxiv]
A group approach to growing as a principal investigator. Greco V✉, Politi K✉, Eisenbarth S✉, Colón-Ramos D✉, Giraldez AJ✉, Bewersdorf J✉ & Berg DN✉. Current Biology. Jun 6, 2022. doi.org/10.1016/j.cub.2022.04.082
From start to finish—a molecular link in wound repair. Yun S & Greco V✉. Science. Feb 11, 2022. doi.org/10.1126/science.abn7411
NEWS
Transitioning through the continuum of differentiation. Nature Reviews Molecular Cell Biology. Dec 7, 2022
Insights & Outcomes: Skin cells, the 22nd amino acid, and data from wearables - Yale News. Nov 22, 2022
2021
Functional cell death, corneoptosis, requires temporally controlled intracellular acidification. Moore J✉ & Greco V✉. PNAS. Jun 1, 2021. doi.org/10.1073/pnas.2106633118
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Park S*, Matte-Martone C*, Gonzalez DG, Lathrop EA, May DP, Pineda CM, Moore JL, Boucher JD, Marsh ED, Schmitter A, Cockburn K, Markova O, Bellaiche Y, Greco V✉. Nature Cell Biology. May 6, 2021. doi.org/10.1038/s41556-021-00670-5 [bioRxiv]
3D Super-Resolution Deep Tissue Imaging in Live Mice. Velasco MG, Zhang M, Antonello J, Yuan P, Allgeyer E, May DP, M’Saad O, Kidd P, Barentine A, Greco V, Grutzendler J, Booth M & Bewersdorf J✉. Optica. Mar 25, 2021. doi.org/10.1364/OPTICA.416841
NEWS
Collective Efforts to Increase Diversity, Equity, and Inclusion in the Genetics Department Make Steady Progress - Yale Medicine. Aug 27, 2021
Leaders in the making: Women PhD students in STEM take initiative to define their leadership - Yale Medicine. Jul 6, 2021
Tracking skin and immune cell interactions. Nature Cell Biology. May 6, 2021
How the skin’s immune system cells coordinate defense against threats - Yale News. May 6, 2021
Valentina Greco Shares Her Advice for Promoting Gender Equity in STEM - NYSCF. Mar 29, 2021
Dr. Valentina Greco serves as Genetics’ Inaugural Vice Chair of Diversity; Establishes Diversity Advisory Committee - Yale Medicine. Mar 23, 2021
2020
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V & Regot S✉. Developmental Cell. Oct 21, 2020. doi.org/10.1016/j.devcel.2020.09.013
NEWS
Stem Cell Podcast Ep. 172: “Organ Regeneration” Featuring Dr. Valentina Greco - The Stem Cell Podcast. Jul 14, 2020
Greco Scoops Multiple Awards for Continued Dedication to Mentorship - Yale Medicine. Jan 6, 2020
2019
Hair follicle regeneration suppresses Ras-driven oncogenic growth. Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S & Greco V✉. Journal of Cell Biology. Oct 7, 2019. doi.org/10.1083/jcb.201907178
Lymph vessels find a hairy niche. Kam CY✉ & Greco V✉. The EMBO Journal. Sept 17, 2019. doi.org/10.15252/embj.2019103219
Suzanne Eaton: 1959–2019. Greco V✉ & Ghosh S✉. Nature Cell Biology. Aug 22, 2019. doi.org/10.1038/s41556-019-0387-1
Flexibility sustains epithelial tissue homeostasis. Tai K, Cockburn K✉ and Greco V✉. Current Opinion in Cell Biology. May 29, 2019. doi.org/10.1016/j.ceb.2019.04.009
NEWS
New hair follicles can corral skin cancer - Yale News. Sep 5, 2019
Remembering Carolyn W. Slayman - Yale Medicine. Apr 9, 2019
Scientist finds skin deep is very deep - Yale Medicine. Feb-Mar, 2019
Stem Cell Collection 2020 - Rockefeller University Press. 2019
2018
Flexible fate determination ensures robust differentiation in the skin hair follicle. Xin T, Gonzalez DG, Rompolas P and Greco V✉. Nature Cell Biology. Nov 12, 2018. doi.org/10.1038/s41556-018-0232-y
Positional stability and membrane occupancy define skin fibroblast homeostasis in vivo. Marsh E, Gonzalez DG, Lathrop EA, Boucher J and Greco V✉. Cell. Nov 8, 2018. doi.org/10.1016/j.cell.2018.10.013
Homeostatic stem cell self-renewal is driven by local differentiation. Mesa K*, Kawaguchi K*, Cockburn K*✉, Gonzalez DG, Boucher J, Xin T, Klein AM✉ and Greco V✉. Cell Stem Cell. Nov 1, 2018. doi.org/10.1016/j.stem.2018.09.005
NEWS
Revitalizing Aging Skin through Diet. Cell. Nov 27, 2018
Neighbors hold key to the renewal of stem cells - Yale News. Sep 27, 2018
Women in Stem Cell Science: Part I. Stem Cell Reports. Sept 11, 2018
Microscopy lights up stem cells in action. PNAS. Jun 12, 2018
How Cells Cooperate to Grow Hair, Replace Skin - Yale News. 2018
2017
Correction of aberrant growth preserves tissue homeostasis. Brown S*, Pineda CM*, Xin T, Boucher J, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski J, Beronja S✉ and Greco V✉. Nature. Aug 17, 2017. doi.org/10.1038/nature23304
Tissue-scale coordination of cellular behavior promotes epidermal wound repair in live mice. Park S, Gonzalez D, Guirao B, Boucher J, Cockburn K, Marsh E, Mesa K, Brown S, Rompolas P, Haberman A, Bellaïche Y and Greco V✉. Nature Cell Biology. Mar 1, 2017. doi.org/10.1038/ncb3472
Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers. Sun, T✉, Haberman A and Greco V✉. Journal of Investigative Dermatology. Feb 1, 2017. doi.org/10.1016/j.jid.2016.08.033
NEWS
How Cell Biologists Work: Valentina Greco on cultivating a passionate research team - ASCB. Oct 13, 2017
Policing Tumorigenesis within the Skin: Good Outs Bad. Cell Stem Cell. Aug 19, 2017
Healthy skin rejects cancer. Nature. Aug 2, 2017
Good cellular neighbors combat incipient cancers - Yale News. Aug 2, 2017
Yale Researchers Capture Wound Repair in Live Mice - Yale News
2016
The thrill of scientific discovery and leadership with my group. Greco V✉. Molecular Biology of the Cell. Nov 1, 2016. doi.org/10.1091/mbc.E16-06-0373
Live imaging of stem cells: answering old questions and raising new ones. Park S, Greco V✉, and Cockburn K✉. Current Opinion in Cell Biology. Jul 27, 2016. doi.org/10.1016/j.ceb.2016.07.004
Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Rompolas P*, Mesa KR*, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM✉ and Greco V✉. Science. Jun 17, 2016. doi.org/10.1126/science.aaf7012
Hardwiring Stem Cell Communication through Tissue Structure. Xin T, Greco V✉ and Myung P✉. Cell. Mar 10, 2016. doi.org/10.1016/j.cell.2016.02.041
NEWS
An Interview with Valentina Greco - Sep 12, 2016
Fate by Chance, not by Choice: Epidermal Stem Cells Go Live. Cell Stem Cell. Jul 7, 2016
Research note: Images show how stem cells create just enough tissue - Yale News. May 26, 2016
2015
Intravital imaging of hair follicle regeneration in the mouse. Pineda CM*, Park S*, Mesa KR, Wolfel M, Gonzalez D, Haberman A, Rompolas P✉, and Greco V✉. Nature Protocols. Jul 10, 2015. doi.org/10.1038/nprot.2015.070
The dynamic duo: niche/stem cell interdependency. Mesa KR, Rompolas P and Greco V✉. Stem Cell Reports. Jun 9, 2015. doi.org/10.1016/j.stemcr.2015.05.001
Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez D, Blagoev K, Haberman A and Greco V✉. Nature. Jun 4, 2015. doi.org/10.1038/nature14306
NEWS
Follicle Stem Cells Done in by Neighbors - ASCB. Jun 19, 2015
Research in the News: Tiny hair follicle offers big clues about the life and death of stem cells - Yale News. Apr 6, 2015
2014
Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging. Brown S and Greco V✉. Cell Stem Cell. Dec 4, 2014. doi.org/10.1016/j.stem.2014.11.006
Establishing an academic laboratory: mentoring as a business model. Greco V✉. Molecular Biology of the Cell. Nov 1, 2014. doi.org/10.1091/mbc.e14-06-1079
Spontaneous tumor regression in keratoacanthomas is driven by Wnt /Retinoic Acid signaling cross-talk. Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ and Greco V✉. Nature Communications. Mar 26, 2014. doi.org/10.1038/ncomms4543
β-catenin activation regulates tissue growth via a non-cell autonomous mechanism within the hair stem cell niche. Deschene RE*, Myung P*, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I and Greco V✉. Science. Mar 21, 2014. doi.org/10.1126/science.1248373
Stem cell dynamics in the hair follicle niche. Rompolas P✉ and Greco V✉. Seminars in Cell & Developmental Biology. Jan-Feb 2014. doi.org/10.1016/j.semcdb.2013.12.005
NEWS
A key link between tumors and healthy tissue identified - Yale News. Mar 20, 2014
2013
Spatial organization within a niche as a determinant of stem cell fate. Rompolas P, Mesa KR and Greco V✉. Nature. Oct 24, 2013. doi.org/10.1038/nature12602
Linking morphogen and chromatin in the hair follicle. Mesa KR and Greco V✉. Developmental Cell. Apr 29, 2013. doi.org/10.1016/j.devcel.2013.04.009
The death and growth connection. Greco V✉. Nature Reviews Molecular Cell Biology. Jan 1, 2013. doi.org/10.1038/nrm3490
NEWS
In stem cells, like real estate, location is most important factor - Yale News. Oct 6, 2013
2012
Live imaging of stem cell and progeny behavior in physiological hair follicle regeneration. Rompolas P, Deschene ER, Zito G, Gonzalez DG, Saotome I, Haberman AM and Greco V✉. Nature. Jul 26, 2012. doi.org/10.1038/nature11218
NEWS
Reporting live from the epidermal stem cell compartment! Cell Stem Cell. Aug 3, 2012
In real time, Yale scientists watch stem cells at work regenerating tissue - Yale News. Jul 1, 2012
2010
Compartmentalized organization: a common and required feature of stem cell niches? Greco V✉ and Guo S. Development. May 15, 2010. doi.org/10.1242/dev.041103
Pre-Greco Lab (2009 and earlier)
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration. Greco V*, Chen T*, Rendl M, Schober M, Pasolli HA, Stokes N, Cruz-Racelis JD and Fuchs E✉. Cell Stem Cell. Feb 6, 2009. doi.org/10.1016/j.stem.2008.12.009
Mice cloned from skin cells. Li J*, Greco V*, Guasch G*, Mombaerts P✉ and Fuchs E✉. PNAS. Feb 20, 2007. doi.org/10.1073/pnas.0611358104
Defining the epithelial stem cell niche in skin. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry W, Rendl M and Fuchs E✉. Science. Jan 16, 2004. doi.org/10.1126/science.1092436
Argosomes: A Potential Vehicle for the Spread of Morphogens through Epithelia. Greco V, Hannus M and Eaton S✉. Cell. Sep 7, 2001. doi.org/10.1016/S0092-8674(01)00484-6
DNA re-replication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Di Leonardo A*, Hussain KS*, Linke SP, Greco V, Seidita G and Wahl GM✉. Cancer Research. Mar 1, 1997.